7,369 research outputs found

    Investigation of E. coli Heptosyltransferase I Dynamics

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    Quantifying Equine Behavior Utilizing GPS

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    GPS tracking systems have been around for many years and are used to track, map, determine precise locations, navigate, and get precise time measurements on a number of different animals, devices, vehicles, and much more. The use of GPS tracking systems on animals has been a huge breakthrough in the cattle industry since this means farmers no longer have to monitor their cattle manually, but can do remotely. The research that has previously been done on cattle tracking can now be applied to horses, although as horses are used in a much different manner than cattle the data will go on to indicate the overall movement of the horse, the use of pasture, and time spent grazing. This information can then be used to potentially lower cost of living for horses as well as potentially improve quality of life for them, since we may be able to detect changes in movement or behavior which are indicative of injury or other problems. Technological advances over the past several years makes the use of GPS cost effective and open the opportunity to monitor different types of animals remotely, making it easier to alert farmers, or other horse owners, to possible problems on their property. Taking all of this into consideration, the question at hand is: how can the use of a GPS collar indicate behavioral changes and pasture usage of horses? I hypothesized that the GPS monitors would be able to detect small movements of horses which would indicate position in their pasture, or grazing, and also detect movements that are outside of each horse\u27s normal movements which may indicate some kind of illness or issue in their pasture. The results of this study show that using GPS to track equine movement can indicate their behavior. Though without more precise devices, it is difficult to differentiate between certain movements like resting or grazing

    In search for a widely applicable and accepted software quality model for software quality engineering

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    Software Quality Engineering is an emerging discipline that is concerned with improving the approach to software quality. It is important that this discipline be firmly rooted in a quality model satisfying its needs. In order to define the needs of this discipline, the meaning of quality is broadly defined by reviewing the literature on the subject. Software Quality Engineering needs a quality model that is usable throughout the software lifecycle and that it embraces ail the perspectives of quality. The goal of this paper is to propose a quality model suitable for such a purpose, through the comparative evaluation of existing quality models and their respective support for Software Quality Engineering

    Alien Registration- Cote, Helen M. (Caswell, Aroostook County)

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    https://digitalmaine.com/alien_docs/23664/thumbnail.jp

    EuroSpine Task Force on Research: support for spine researchers

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    In recognition of the value of research to the practice of spine care, Federico Balagué and Ferran Pellisé, at the time President and Secretary for EuroSpine, asked Margareta Nordin to set up a Task Force on Research (TFR) for EuroSpine during summer 2011. The concept was to stimulate and facilitate a research community within the society, through two main functions: (1) distribution of EuroSpine funds to researchers; (2) develop and deliver research training/education courses. What has the EuroSpine TFR accomplished since its inception

    Assessment of slope failures off Vancouver Island revealed in EM300 multibeam bathymetry data

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    Multibeam bathymetric data acquired off Vancouver Island across the accretionary prism of the Cascadia subduction zone reveal a prominent segmentation of the deformation front with dominant azimuths of the ridges at ~120° and ~150° and abundant submarine landslides. Both these ridge-orientations are oblique to the direction of subduction (~45°). Ridges at a strike of ~120° show dominantly rectangular-shaped failure head-scarps and intact blocks of sediments within the failed sediment mass, whereas ridges with an azimuth of ~150° show curved head-scarps and incoherent debris in the failure mass. We propose that this systematic change in failure-style is related to the underlying thrust fault system producing steeper and taller ridges for azimuths around 150°, but less steep and tall ridges at 120°. Thus, debris-flow style failure is simply a result of higher kinetic forcing of the down-sliding sediment mass: more mixing and destruction of the coherent blocks for taller and steeper ridges, and blocks of intact sediment for gentle slopes and less elevated ridges. A segmentation of the deformation front and ridge alignment into two dominant azimuths could be a result of: a) complex interaction and competing forces from overall slab-pull (45°), b) re-activated faults orientated almost N-S (~175°) on the oceanic plate and overlying sediment cover (reflected in the magnetic stripes and abyssal plain strike-slip faulting), and c) relative orientation of the back-stop off Vancouver Island and accreted terranes (at ~127° following the coastline between Nootka Island and Port Renfrew). Extensional faulting is observed only at ridges with debris-flow style failure, which also are the ridges with larger height and steeper slopes. These extensional faults may be the result of over-steepening of the ridges and collapse of the sediment pile that can no longer withstand its own weight due to limited internal shear strength

    Collective Excitations, NMR, and Phase Transitions in Skyrme Crystals

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    At Landau level filling factors near nu =1, quantum Hall ferromagnets form a Skyrme crystal state with quasi-long-range translational and non-collinear magnetic order. We develop an effective low energy theory which explains the presence in these systems of magnetic excitations at low energies below the Larmor gap (Delta) and which predicts a dramatic enhancement of the nuclear spin relaxation rate by a factor of 1000. The effective theory predicts a rich set of quantum and classical phase transitions. Based in part on accurate time-dependent Hartree-Fock calculations of the ordered state collective excitation spectrum, we discuss aspects of the T-nu-Delta crystal phase diagram.Comment: 4 pages REVTEX file and 3 postscript figure

    Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.

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    Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste Homologue 2 (EZH2), or that SS18-SSX is able to directly recruit PRC2 to aberrantly silence target genes. This is of potential therapeutic value as several EZH2 small molecule inhibitors are entering early phase clinical trials. In this study, we first confirmed EZH2 expression in the 76% of human synovial sarcoma samples. We subsequently investigated EZH2 as a therapeutic target in synovial sarcoma in vitro. Knockdown of EZH2 by shRNA or siRNA resulted in inhibition of cell growth and migration across a series of synovial sarcoma cell lines. The EZH2 selective small-molecule inhibitor EPZ005687 similarly suppressed cell proliferation and migration. These data support the hypothesis that targeting EZH2 may be a promising therapeutic strategy in the treatment of synovial sarcoma; clinical trials are initiating enrollment currently
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